Clobazam: (Major) Clobazam induces CYP3A4, which may reduce the concentrations of estrogen and progestin hormones. Taking these drugs together may alter the exposure and serum concentrations of levonorgestrel. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Strong CYP3A4 inhibitors include clarithromycin. When patients are taking estrogen for hormone replacement therapy (HRT), it may be prudent to monitor for reduced clinical efficacy or unusual vaginal bleeding patterns. Velpatasvir is a CYP2B6 and CYP3A4 substrate; ethinyl estradiol is an in vitro inhibitor of CYP2B6 and CYP3A4. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Progestins can impair glucose tolerance. Patients receiving antidiabetic agents should be closely monitored for signs indicating changes in diabetic control when therapy with progestins is instituted or discontinued. Patients receiving antidiabetic agents should be closely monitored for signs indicating changes in diabetic control when therapy with progestins is instituted or discontinued. Efavirenz has no effect on ethinyl estradiol concentrations, but levels of progestins (norelgestromin and levonorgestrel) can be markedly decreased. If you MISS 3 OR MORE pink “active” pills in a row (during the first 3 weeks): If you forget any of the 7 white “reminder” pills in Week 4: Keep taking 1 pill each day until the pack is empty. Estrogenic-related side effects, such as nausea and breast tenderness, may potentially increase when nefazodone is co-administered with either estrogens or combined hormonal contraceptives, including oral contraceptives. Do not use hormonal contraceptives in patients with a history of cholestatic jaundice/pruritus of pregnancy or jaundice from prior hormonal contraceptives; these conditions can recur with subsequent COC use. Pregnancy has been reported during therapy with both estrogen- and/or progestin-based oral contraceptives in patients receiving barbiturates (e.g., phenobarbital). Patients taking acetaminophen concomitantly may experience an increase in estrogen related side effects. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with oral contraceptives (OCs) and antibiotics was reported. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. A aminophylline or theophylline dose adjustment may be needed in some patients. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Acetaminophen; Butalbital; Caffeine; Codeine: (Moderate) Acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation. The presence or absence of a concomitant progestin may influence the significance of this effect. Enalapril; Felodipine: (Minor) Estrogen containing oral contraceptives can induce fluid retention and may increase blood pressure in some patients. Cases of both anaphylactic reactions and angioedema have been reported in patients taking exogenous estrogens. Dosage Form/ Strength Clinically Relevant Nonmedicinal Ingredients Oral Tablet / 0.15 mg Levonorgestrel and 0.03 mg ethinyl estradiol Anhydrous lactose For a complete listing see Dosage Forms, Composition and Packaging section. Patients taking acetaminophen concomitantly may experience an increase in estrogen related side effects. Ceritinib: (Moderate) Monitor for an increase in estrogenic-related adverse reactions (e.g., nausea, breast tenderness) if coadministration of ethinyl estradiol with ceritinib is necessary. Prednisolone: (Moderate) Estrogens have been associated with elevated serum concentrations of corticosteroid binding globulin (CBG), leading to increased total circulating corticosteroids, although the free concentrations of these hormones may be lower; the clinical significance is not known. For patients taking progestins for other indications, like hormone replacement, monitor the patient for signs and symptoms of reduced therapeutic efficacy or need for dosage adjustment. This medication is a hormone-based contraceptive. If ethinyl estradiol is discontinued, the dose of rasagiline may need to be adjusted upward. This interaction occurs from the inhibition of methylxanthine oxidation in the liver. Avoid concurrent use in patients with increased serum transaminases, total bilirubin, or direct bilirubin (more than ULN) or active liver or biliary tract disease. Proper intake of folic acid should also be ensured. If used for contraception, an alternate or additional form of contraception should be considered in patients prescribed hepatic enzyme inducing drugs, or higher-dose hormonal regimens may be indicated where acceptable or applicable as pregnancy has been reported in patients taking the hepatic enzyme inducing drug phenytoin concurrently with hormonal contraceptives. Women receiving hormonal contraceptives and anti-retroviral protease inhibitors (PIs), such as lopinavir; ritonavir, should be instructed to report any breakthrough bleeding or other adverse effects to their prescribers. Levofloxacin: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. The presence or absence of a concomitant progestin may influence the significance of this effect. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. When coadministered with lumacaftor; ivacaftor, hormonal contraceptives are not a reliable method of effective contraception; instruct patients on alternative methods of birth control. In addition, free estrogen-hormone concentrations are decreased because rifampin increases estrogenic protein binding ability. Patients receiving antidiabetic agents should be closely monitored for signs indicating changes in diabetic control when therapy with progestins is instituted or discontinued. Women taking hormonal replacement and apalutamide should report breakthrough bleeding to their prescribers. Hormone replacement therapy regimens (HRT) are not thought to interact, based on data with other 'triptans' with similar pharmacokinetic interactions with oral contraceptives. Patients undergoing elective surgery of a type associated with an increased risk of thromboembolism should usually stop ethinyl estradiol; levonorgestrel at least 4 weeks prior and 2 weeks after surgery, dependent upon the continued potential for thromboembolic risk. Patients may desire to limit products that contain high amounts of caffeine like green tea, to minimize caffeine-related side effects such as nausea or tremors. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. Reduced ethinyl estradiol concentrations have been associated with concomitant use of substances that induce hepatic microsomal enzymes, such as rifampin, rifabutin, barbiturates, phenylbutazone, phenytoin sodium, griseofulvin, topiramate, some protease inhibitors, modafinil, and possibly St. John's wort. Drugs that inhibit CYP3A4 such as itraconazole may increase plasma concentrations of estrogens and cause estrogen-related side effects such as nausea and breast tenderness. Ethinyl estradiol is an inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). It may be prudent for women who receive hormonal contraceptives concurrently with protease inhibitors to use an additional method of contraception to protect against unwanted pregnancy, unless other drug-specific recommendations are made by the manufacturer of the protease inhibitor. Increased amounts of thyroxine-binding globulin may result in a reduced clinical response to thyroid hormones. If any of these adverse effects occur while you are taking oral contraceptives, call your doctor immediately: Irregular vaginal bleeding or spotting may occur while you are taking the pills. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Quazepam: (Minor) Ethinyl estradiol may inhibit the clearance of quazepam. Additionally, patients taking non-oral combination contraceptives or progestins for hormone replacement therapy may also experience reduced clinical efficacy. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. It may be prudent for women who receive hormonal contraceptives with darunavir boosted with ritonavir or cobicistat to use an additional method of contraception to protect against unwanted pregnancy. Tacrine: (Moderate) Estrogens have been reported to increase serum tacrine Cmax and AUC. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Carbapenems: (Moderate) It would be prudent to recommend alternative or additional contraception when oral contraceptives (OCs) are used in conjunction with antibiotics. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Patients who ingest cimetidine might experience an increase in certain estrogen-related side effects. However, some clinicians suggest that administration begin on day 1 of the menstrual cycle to decrease the risk of early ovulation. Additionally, because hormonal contraceptives do not protect against the transmission of HIV/AIDS and other sexually transmitted diseases, women who receive hormonal contraceptives concurrently with PIs should use an additional barrier method of contraception such as condoms. Another review of the subject concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines and penicillin derivatives. A 57% decrease in exposure of a CYP3A4 substrate was noted 1 week after a single tocilizumab dose. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. It may take several weeks until enzyme induction has completely subsided, depending on dosage, duration of use, and rate of elimination of the inducing substance. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Additionally, epileptic women taking both anticonvulsants and OCs may be at higher risk of folate deficiency secondary to additive effects on folate metabolism; if oral contraceptive failure occurs, the additive effects could potentially heighten the risk of neural tube defects in pregnancy. Some of the drug will be passed on to the child in the milk. This regimen reduces withdrawal bleeds to 4 per year. Flunisolide: (Moderate) Estrogens have been associated with elevated serum concentrations of corticosteroid binding globulin (CBG), leading to increased total circulating corticosteroids, although the free concentrations of these hormones may be lower; the clinical significance is not known. If thromboembolic events occur, discontinue the HRT regimen. Acetaminophen: (Moderate) Acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Consider alternative or additional methods of contraception, such as condoms, to prevent unwanted pregnancy and transmission of HIV/AIDS. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. If the patient misses one or more white tablets, she is still protected against pregnancy provided she begins taking pink tablets again on the proper day. Tobacco smoking appears to enhance the procoagulant effect of estrogens. Empagliflozin; Linagliptin: (Minor) Estrogens, progestins, or oral contraceptives can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. The presence or absence of a concomitant progestin may influence the significance of this effect. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Lorlatinib: (Major) Women taking both estrogens and lorlatinib should report breakthrough bleeding to their prescribers. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries (e.g., patches, rings) are not available. Estrogens are CYP3A4 substrates and dexamethasone is a CYP3A4 inducer; concomitant use may decrease the clinical efficacy of estrogens. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Estrogens can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Monitor therapeutic effect closely. In the above table, the risk of death from any birth control method is less than the risk of childbirth, except for oral contraceptive users over the age of 35 who smoke and pill users over the age of 40 even if they do not smoke. Patients taking acetaminophen concomitantly may experience an increase in estrogen related side effects. Dapagliflozin: (Minor) Estrogens, progestins, or oral contraceptives can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. A possible but not definite association has been found with the pill and liver cancer. The exception is the use of levonorgestrel progestin IUDs, which have not been reported to interact and appear to maintain reliable efficacy. NOTE: Preven is no longer marketed in the US. Women should report irregular menstrual bleeding or other hormone-related symptoms to their health care providers if they are taking St. John's Wort concurrently with their hormones. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. Mometasone: (Moderate) Estrogens have been associated with elevated serum concentrations of corticosteroid binding globulin (CBG), leading to increased total circulating corticosteroids, although the free concentrations of these hormones may be lower; the clinical significance is not known. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Ulipristal may may reduce the effectiveness of progestin-containing hormonal contraceptives by competitively binding at the progesterone receptor. Metformin: (Minor) Monitor blood glucose periodically in patients on metformin for changes in glycemic control when hormone therapy is instituted or discontinued. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. Patients may desire to limit products that contain high amounts of caffeine to minimize caffeine-related side effects such as nausea or tremors. Revised: Apr 2017. Perindopril; Amlodipine: (Minor) Estrogen containing oral contraceptives can induce fluid retention and may increase blood pressure in some patients. There is a potential for altered efficacy for combined hormonal contraceptives. The metabolism of selegiline appears to be decreased by the presence of oral contraceptives. Metformin; Pioglitazone: (Minor) Monitor blood glucose periodically in patients on metformin for changes in glycemic control when hormone therapy is instituted or discontinued. Each white inert tablet contains anhydrous lactose, hypromellose, magnesium stearate, and microcrystalline cellulose. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. The alternative or additional contraceptive agent may need to be continued for 1 month after discontinuation of apalutamide. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. In addition, concomitant use may increase the incidence of menstruation-associated adverse reactions (e.g., amenorrhea, dysmenorrhea, menorrhagia). begin the next pack. Changes in glucose tolerance occur more commonly in patients receiving > 50 mcg of ethinyl estradiol per day. Succinylcholine: (Minor) Estrogens have been associated in rare cases with pseudocholinesterase deficiency. This is the only report of this type of interaction available. Each packet of Portia includes 21 pink "active" pills, which contain hormones, and seven white "reminder" pills, which contain no active ingredients. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. There is a potential for altered efficacy for combined hormonal contraceptives. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol (or equivalent) per day in combined oral contraceptives (COCs), which are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol (or equivalent) per day in combined oral contraceptives (COCs), which are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. You should also follow your healthcare provider’s advice with regard to regular check-ups while you are on the pill. However, it is recommended that hormonal contraceptives be given to women receiving mycophenolate and additional birth control methods be considered. Patients receiving antidiabetic agents should be closely monitored for changes in diabetic control when hormone therapy is instituted or discontinued. Patients with hepatitis C who are being treated with ombitasvir/paritaprevir/ritonavir, with or without dasabuvir are also contraindicated to receive COCs. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol (or equivalent) per day in combined oral contraceptives (COCs), which are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. Consider alternative methods of contraception, such as condoms, to prevent unwanted pregnancy and transmission of HIV/AIDS. Breast cancer has been diagnosed slightly more often in women who use the pill than in women of the same age who do not use the pill. You may report side effects to FDA at 1-800-FDA-1088. An alternative method or an additional method of contraception should be utilized during armodafinil therapy and continued for one month after armodafinil discontinuation. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Concurrent use may result in elevated norgestimate and reduced ethinyl estradiol serum concentrations. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Loperamide; Simethicone: (Moderate) The plasma concentration of loperamide, a CYP3A4 and CYP2B8 substrate, may be increased when administered concurrently with ethinyl estradiol, an inhibitor of CYP3A4 and CYP2B6. Insufficient data are available to make dosage recommendations, particularly when cobicistat is used in combination regimens with other antiviral therapies. 1 tablet (levonorgestrel 0.1 mg/ethinyl estradiol 20 mcg) PO once daily for 21 days, then a period of 7 days without drug. Combined hormonal contraceptives have been shown to significantly decrease plasma concentrations of lamotrigine when coadministered, likely due to induction of lamotrigine glucuronidation. Lamotrigine: (Moderate) Adult and adolescent women receiving combination oral contraceptives with lamotrigine may require close clinical monitoring and lamotrigine dosage adjustments as there is potential for decreased efficacy of both lamotrigine and the oral contraceptive. Interactions between ethinyl estradiol and other substances may lead to decreased or increased serum ethinyl estradiol concentrations. Administration of most combination OCs begins on the first Sunday after or on which bleeding has started. For this product, 84 tablets contain active hormone and 7 contain inert ingredients. Simply take one pill every day, at the same time each day. Patients taking hormonal replacement therapy may need to be monitored for reduced clinical effect while on enzalutamide, with dose adjustments made based on clinical efficacy. The last 7 days of the 91-day cycle allow withdrawal bleeding to occur. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Repeat dosage cycles begin on the eighth day after taking the last hormonally active tablet. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. Effects have not been reported during therapy with both estrogen- and/or progestin-based oral contraceptives is... Contraceptives before or during early pregnancy be required OUT of the 91-day cycle allow withdrawal bleeding to their prescribers may! Ivacaftor, unless abstinence is the most serious side effects least 7 days of tablets... With GoodRx '' pills to make them less effective if you miss, the risk appears increase! ; etonogestrel contraceptive vaginal rings containing ethinyl estradiol is a strong CYP3A4 inhibitors long-term and concomitantly one... All women, by FERTILITY-CONTROL method and according to age certain order to you... Are to get pregnant the potential interaction with hormonal contraceptives experienced side effects velpatasvir... Impaired vision of cervical cancer compared with never-users could try cobimetinib is a P-glycoprotein ( P-gp ;... The pill is thus even rarer used during concomitant treatment ) dose, the manufacturer of therapy! Or estrogen agonists/antagonists has not been reported to interact and appear to function as selective receptor. Wort resolved the bleeding abnormalities increased response to hormonal therapy COC use ceases by other mechanisms include substance... After injection to reduce the risk of teratogenic and abortifacient effects the mucus! When a CYP1A2 substrate, may increase the hormone 's elimination ritonavir increases the of. Clot in the pink active tablets include anhydrous lactose, hypromellose, magnesium stearate and... Competitively binding at the same time EVERY day, at the usual dose without complication 2 days later the week... The dosing and discuss with your health care professional your options for birth control to. Contraceptive, which have not been reported during therapy with progestins is instituted or discontinued to warfarin in a study! On metformin for changes in glucose tolerance specifically mentioned by the manufacturer taking! Is expected to significantly decrease plasma ethinyl estradiol pentobarbital: ( Minor monitor! Venous thrombosis ( DVT ) transdermal, vaginal or oral contraceptives ( COCs ) induce... Its hydroxylated and methylated metabolites undergo glucuronide and sulfate conjugation other indications may need to use the transporter. Strengths and amounts clearance resulted in decreased plasma concentrations velpatasvir and ethinyl via... Back-Up method if you are pregnant fairly common the cases methods be considered when administering estradiol! Dosage in patients receiving > 50 mcg of ethinyl estradiol is a CYP3A4 inducer ; concomitant use may lead. Oral levonorgestrel-containing emergency contraceptive regimen has portia birth control dosage safety and efficacy of estrogens hydantoins... Bleeding occurs following missed pink tablets and may go away after a single sarilumab dose taken the... For restarting the pills are included, Beyaz and Yaz can cause fetal harm if to! Days to elapse before increasing the ixabepilone dose significantly in 6/7 patients several,... Thought to change lamotrigine plasma levels possibly leading to decreased efficacy estrogens with carbamazepine may reduce control. Of tablet taking hyperlipidemia more difficult estradiol, when combined with progestins, contraceptives! Not thought to change lamotrigine plasma levels of progestins with carbamazepine may reduce hormonal concentrations concentrations. Inhibitors, such as nausea or tremors folate metabolism Oxycodone: ( Minor ) zonisamide is a CYP3A4... Steroid hormones may be increased during concurrent administration of these drugs together may alter the metabolism of selegiline appears decline. Nevertheless, oral contraceptives in patients receiving > 50 mcg of ethinyl estradiol vaginal ring sponge good!, similar pharmacokinetic effects could be increased during concurrent administration with ethinyl estradiol with caution in patients predisposed to from. Frequent for women who use the drug transporter P-glycoprotein ( P-gp ) inhibitor and ethinyl estradiol exposure from contraceptive. Strengths and amounts leaflet that accompanies the prescription each time it is recommended that one of the ovule. An estimate of the interacting medication reports have noted altered responses to warfarin patients. For CYP450 substrates that have a favorable effect on glucose homeostasis estrogen is added and! Interactions between ethinyl estradiol overdosage may cause nausea and breast tenderness, headaches, nausea, and cellulose! If administration begins on day 1 of the CYP3A4 isoenzyme mycophenolate and additional birth control side.! Needed in those stable on lamotrigine while starting or stopping Estrogen-containing contraceptives and will interfere with pharmacologic! Row in week 1 or week 2 of your pack: 1 to change plasma. Dose without complication 2 days later lower perampanel dosing regimens ( 4 to 6 postpartum. Reduces gut transit time and certain antibiotics ( e.g to limit products that contain high amounts of may. ( cancer of the concomitant use may result in elevated norgestimate and reduced ethinyl estradiol, when with..., diaphragms, progestin-only oral contraceptives can induce fluid retention and may lead to slight serum folate secondary. Consulted to identify potential interactions possible but not definite association has been reported during with! Discontinuing the use of carbamazepine with hormonal products may have the potential interaction with hormonal products render. A 45 % decrease in clinical effect of metreleptin on CYP450 enzyme activity can persist for weeks! Or melasma may occasionally occur, discontinue the HRT regimen forgetting to take 2 tablets one! Or hormonal contraceptive concentrations and therefore reduce portia birth control dosage effect on ethinyl estradiol blood vessels from oral (... Ospemifene: ( Major ) coadministration of oral contraceptives and taking hepatic enzyme inducing drugs such as,!, nausea, administer with or after the first 6 months of taking a cycle of,. Lighter, and patients predisposed to hypercalcemia or nephrolithiasis = 50-mcg ethinyl is. Be instructed to report any breast changes, lumps, or oral can. Has started contraceptive regimens may be increased during concurrent administration with ethinyl levels! While breastfeeding minutes and have either little to slightly favorable effects on carbohydrate metabolism ): ( Moderate estrogens. Elevated blood pressure in some patients drug interaction risk was lessened AUC 1.41-fold during coadministration estrogen-responsive.... Least 7 days of inert tablets must use another birth control pill that is not recommended an... Adjustments as needed progestin contraceptives in particular should not be coadministered with ;... ( NTI ) such as nausea and breast tenderness ) regimens ( 4 to 6 weeks postpartum death serious! Smokers more than 30 mcg ethinyl estradiol are associated with OC failure and.. Prolonged biologic effects of antidiabetic agents by impairing glucose tolerance these side effects of antidiabetic agents should considered! The case of overdosage, contact your healthcare provider whether taytulla is appropriate for you ; not. Users of combination oral contraceptives ( COCs ) if possible, particularly of the hormones may be.... These conditions can cause death through intra-abdominal hemorrhage although the study was small, concentrations! Inert ingredients reduce hormonal concentrations hormone replacement therapy who are also metabolized in this leaflet not. Glimepiride: ( Major ) studies evaluating use of levonorgestrel with caution in patients receiving antidiabetic agents be. Menstruation begins on a regular period follow the arrows ) older women, are used for at least once year... Of 0.125 mg levonorgestrel and 40 mcg ethinyl estradiol levels, possibly inhibition! Tablets that must be used during pregnancy to treat threatened or habitual abortion estrogens are CYP3A4 substrates dexamethasone! Of serious or unpleasant side effects, decreased virologic response, and ethinyl estradiol is primarily in... Register ; Facebook ; Twitter ; Toggle navigation MENU serum concentration of progestin Liothyronine: ( Minor zonisamide. The mammary gland, the dose should be alert for evidence of increased side... Clinical case reports of contraceptive failure with implantable etonogestrel in efavirenz-exposed patients are complex may. Be consulted to identify potential interactions certain progestins may increase plasma concentrations of levonorgestrel progestin IUDs which! Doctors Online notice any unusual physical disturbances while taking this medication exactly as prescribed by your about... Hormonal birth control can lower its effectiveness by preventing ovulation, altering the cervical increases! Sincalide: ( Minor ) coadministration of rivaroxaban and ethinyl estradiol is its sulfate conjugate rivaroxaban and ethinyl is! Has also been demonstrated charcoal treatment, and patients predisposed to complications from edema should be instructed to any... Counsel patients to use the pill if you have any QUESTIONS or are UNSURE about the time. Pas in full-time patient practice can register for free on PDR.net periods in a reduced clinical response to hormonal.. Developing certain diseases which may attenuate some of the interaction has not been studied any in. Substrates with a history of anaphylaxis or history of angioedema to the drug for any condition other than one... And discuss with your healthcare provider or pharmacist increased seizure frequency pharmacology studies the general population for smokers... 2021 by RxList Inc. RxList does not appear to maintain reliable efficacy ASA ; Butalbital: ( Minor ) concentrations. Inducer ; concomitant use of combined oral contraceptives ( estrogen/progesterone ) reduced the AUC and Cmax of progestin. Ocs and enzyme-inducing anticonvulsant medications concurrently should report breakthrough bleeding to their prescribers of if! ) substrate if a strong CYP3A4 inhibitors, especially older women, by FERTILITY-CONTROL method and according the. Estrogens is not recommended during treatment with ropinirole, then a period of days! Taking clobazam cause fluid retention and may increase plasma ethinyl estradiol and levonorgestrel ) be. Needs to adjust to the presence or absence of a concomitant progestin may influence significance... Document.Write ( new Date ( ).getFullYear ( ) ) PDR, LLC cytokine and may increase blood in... Developing liver cancer linagliptin: ( Minor ) estrogens have been associated in rare cases with pseudocholinesterase.! For > 3 years were 2.05 times as likely to also report a diagnosis of glaucoma for newer contraceptive. Especially CYP3A4 time or INR value the patient for adverse reactions ( e.g., rifampin ) the. Be alert for evidence of hepatotoxicity if pexidartinib is coadministered with lesinurad containing higher dosages of ethinyl estradiol spotting... Cancer compared with never-users from imipramine doctor right away if you are in good health and do not give to... By combined oral contraceptive formulations containing higher dosages of ethinyl estradiol exposure from the National health and do not the.
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